Analytical Data
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Gene name
Neurotrophin-4
- Application
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Biological Activity
1. The ED50 is <5>2.0 × 102 units/mg. 2. Measured by its binding ability in a functional ELISA. When Recombinant Human Neurotrophin-4 is present at 5 μg/mL, can bind Recombinant Mouse TrkB. The ED50 for this effect is 8.676 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human Neurotrophin-4 is present at 5 μg/mL, can bind Recombinant Mouse TrkB. The ED50 for this effect is 8.676 ng/mL.
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Alternative Names
rHuNT-4; NT-5; NTF4; NTF5; NT4
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P34130
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Expression Region
G81-A210
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Protein Length
Full Length of Mature Protein
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurotrophin-4 (NT-4) is a pivotal member of the neurotrophin family, which plays a crucial role in the survival, development, and function of neurons. It specifically aids in the differentiation and maintenance of certain neuronal populations, particularly those in the peripheral and central nervous systems. The significance of NT-4 arises from its ability to bind to the neurotrophin receptors TrkB and p75NTR, which are essential for neuronal signaling. Research has shown that NT-4 can promote neuronal survival and reduce cell death, making it a potential therapeutic candidate for neurodegenerative diseases and nerve injuries. Moreover, NT-4 has been of particular interest in the context of clinical applications, including the treatment of neuropathies and cognitive impairments. The recombinant production of NT-4 has enabled scientists to explore its biological functions and therapeutic potential more extensively. Advancements in recombinant DNA technology have facilitated the large-scale production of NT-4, allowing for in-depth studies into its structure-function relationships and interactions with other cellular components. As research continues, understanding the precise mechanisms by which NT-4 influences neuronal health and plasticity could lead to novel interventions for a range of neurological disorders. Overall, the exploration of NT-4 recombinant proteins represents a promising avenue for both basic neuroscience research and the development of innovative therapeutic strategies.
