Analytical Data
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基因名
H-2K(B) InsB Complex
- Application
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别名
H-2Kd & B2M & InsB (LYLVCGERL)
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种属
Mouse
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01901 (G22-T305)&P61769
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表达区间
P01901 (G22-T305)&P61769 (I21-M119);LYLVCGERL
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分子量
50-55 kDa and 17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The H-2K(B) InsB complex is a crucial subject of study in immunology, particularly in the context of T cell recognition and autoimmune disease. This protein complex, formed between the H-2K(B) MHC class I molecule and the insulin B chain (InsB), serves as a model to investigate how peptide presentation influences T cell activation and specificity. The study of this complex is particularly relevant for understanding Type 1 Diabetes (T1D), a condition characterized by the autoimmune destruction of insulin-producing beta cells in the pancreas. In T1D, specific T cell responses target the InsB peptide, and identifying how the H-2K(B) presents this peptide can provide insights into disease mechanisms and potential therapeutic strategies. Recombinant production of the H-2K(B) InsB complex allows for detailed structural and functional analyses, aiding in the elucidation of the interactions between MHC molecules and T cell receptors (TCRs). Additionally, studying variations in peptide presentation may reveal the genetic and environmental factors contributing to the development of autoimmunity, paving the way for targeted interventions. Overall, research into the H-2K(B) InsB complex is pivotal for advancing our understanding of immune responses and their implications in autoimmune diseases, particularly in devising new approaches for prevention and treatment.
