Analytical Data
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基因名
HLA-E*01:03&B2M&CMV UL40(VMPPRTVIL) Monomer
- Application
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别名
HLA-E*0103 & B2M & CMV UL40 (VMPPRTVIL)
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13747 (G22-I305)&P61769
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表达区间
P13747 (G22-I305)&P61769 (I21-M119)&VMPPRTVIL
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分子量
40-43 kDa and 12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-E*01:03 is a key molecule in the immune system, known for its role in the recognition of conserved viral peptides, particularly from cytomegalovirus (CMV) such as UL40. The recombination of HLA-E*01:03 with β2-microglobulin (B2M) and the UL40 peptide (VMPPRTVIL) is vital for understanding the interactions between innate and adaptive immunity. HLA-E serves as an inhibitory ligand for natural killer (NK) cells and plays a crucial role in presenting non-classical antigens derived from viral infections. The UL40 peptide is particularly significant as it is recognized by HLA-E in the context of CMV infection, influencing the immune response. Studying this monomeric recombinant protein allows researchers to elucidate the structural and functional aspects of HLA-E binding and its implications for immune modulation during viral infections. By characterizing the HLA-E*01:03/B2M/CMV UL40 complex, scientists aim to uncover the mechanisms governing immune tolerance and activation, which may ultimately inform therapeutic strategies for managing CMV-related diseases and enhancing antiviral immunity.
