Cat: IPD-X37954

Recombinant Human CSNK1A1L Protein (Baculovirus),His & GST

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Analytical Data

  • Gene name

    CSNK1A1L

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CSNK1A1L; casein kinase 1, alpha 1-like; casein kinase I isoform alpha-like; MGC33182; CKI-alpha-like; casein kinase I alpha S-like; CK1

  • Species

    Human

  • Source

    Baculovirus

  • Tag

    His;GST

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8N752

  • Expression Region

    T2-N337

  • Protein Length

    Partial

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CSNK1A1L, or Casein Kinase 1 Alpha L, is a member of the casein kinase 1 (CK1) family known for its role in various cellular processes, including cell cycle regulation, signal transduction, and circadian rhythms. Recent studies have indicated that CSNK1A1L is involved in crucial signaling pathways, such as the Wnt/β-catenin pathway, which is significant for development and cancer biology. Due to its regulatory functions and implications in diseases, including neurodegenerative disorders and cancers, the recombinant protein of CSNK1A1L has garnered attention for its potential as a therapeutic target. Investigating the biochemical properties and functional mechanisms of CSNK1A1L through recombinant protein studies can offer insights into its roles in cell signaling and disease progression. Moreover, understanding the structure-function relationship of this protein may lead to the identification of small-molecule inhibitors or activators, which could pave the way for novel treatment strategies. Therefore, the production and characterization of CSNK1A1L recombinant protein are essential steps in elucidating its functions and therapeutic potential in various medical contexts.

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