Analytical Data
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基因名
CDK1
- Application
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别名
Cell division control protein 2 homolog Cell division protein kinase 1 p34 protein kinase CDC2, CDC28A, CDKN1, P34CDC2
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06493
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表达区间
1-297aa
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分子量
38.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK1, or Cyclin-Dependent Kinase 1, is a crucial regulatory enzyme that plays a pivotal role in cell cycle progression, particularly in the transition from G2 to M phase during mitosis. Its activity is tightly regulated by the binding of cyclins, with CDK1-cyclin B complex being essential for the initiation of mitosis. Dysregulation of CDK1 activity can lead to various pathologies, including cancer, making it a significant target for therapeutic intervention. The study of CDK1 recombinant proteins has gained attention in recent years as researchers seek to better understand its structure and function in the cell cycle. By producing CDK1 in a recombinant form, scientists can investigate its biochemical properties, post-translational modifications, and interactions with other cellular proteins in vitro. This research provides insights into the molecular mechanisms governing cell division and the potential development of novel anticancer strategies that target CDK1. The ability to generate large quantities of pure, functional CDK1 protein facilitates high-throughput screening of inhibitors and elucidation of its role in cancer biology, paving the way for new diagnostic and therapeutic approaches. Understanding how CDK1 functions in different cellular contexts further emphasizes its importance not only in cell cycle regulation but also in broader cellular processes, such as DNA damage response and apoptosis. The exploration of CDK1 recombinant proteins thus holds promise for advancing our understanding of cell cycle control and its implications in diseases associated with cell proliferation.
