Analytical Data
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Gene name
HLA-B*40:01&B2M Monomer
- Application
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Alternative Names
HLA-B*4001 & B2M
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAA03719.1 (G25-V309)&P61769
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Expression Region
AAA03719.1 (G25-V309)&P61769 (I21-M119)
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Molecular Weight
40-43 kDa and 11 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-B*40:01 is a specific allele of the human leukocyte antigen (HLA) class I molecule, which plays a crucial role in the immune response by presenting peptides to T cells. Understanding the structural and functional characteristics of HLA-B*40:01, particularly when complexed with β2-microglobulin (B2M), is essential for elucidating its involvement in various diseases, including autoimmune disorders and responses to infectious diseases. The recombinant production of the HLA-B*40:01/B2M monomer enables researchers to analyze its binding affinity, peptide presentation capabilities, and overall stability. Such studies are vital for exploring its implications in transplant immunology, vaccine development, and the design of targeted therapies. By investigating the interactions between this HLA molecule and its associated peptides, researchers aim to uncover mechanisms underlying individual differences in immune responses and susceptibility to diseases, paving the way for personalized medicine approaches. Additionally, the HLA-B*40:01/B2M monomer serves as a valuable tool for developing diagnostic and therapeutic interventions by enhancing our understanding of T cell receptor interactions and the overall dynamics of the immune system. Thus, the study of this recombinant protein stands at the intersection of immunology, molecular biology, and clinical research, contributing to a deeper comprehension of human health and disease.
