Analytical Data
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基因名
MRCKβ
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简介
CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells, with GST labeled tag.
- Application
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种属
Human
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表达系统
Baculovirus
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标签
GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5S2
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表达区间
S2-G473
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRCKβ (Myotonic Dystrophy Kinase Related Cdc42-Binding Kinase β) is a serine/threonine kinase that belongs to the AGC family of kinases and plays a pivotal role in various cellular processes, including cytoskeletal organization, cell migration, and cell proliferation. Its involvement in signal transduction pathways makes MRCKβ a crucial regulator of tumorigenesis and metastasis, particularly in cancer types where cell motility is a key factor. The study of MRCKβ is gaining momentum as researchers seek to understand its functional mechanisms and regulatory networks. Abnormal expression or activity of MRCKβ has been implicated in several diseases, notably cancer, where it may contribute to aggressive phenotypes and poor patient prognosis. Moreover, recent findings suggest that MRCKβ might interact with other signaling molecules such as Rho GTPases, intensifying its role in regulating the actin cytoskeleton and facilitating cancer cell invasion. This has prompted investigations into its potential as a therapeutic target, as inhibiting MRCKβ could diminish the invasive capabilities of cancer cells. Overall, research surrounding MRCKβ recombinant proteins aims to elucidate its biological functions, explore its molecular interactions, and assess its potential in targeted therapies, presenting an exciting frontier in cancer biology and treatment strategies.
