Analytical Data
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Gene name
MST1/STK4
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简介
MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.
- Application
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Alternative Names
Serine/threonine-protein kinase 4; MST1/N; MST1/C; STK4; KRS2
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Species
Human
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Source
Baculovirus
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Tag
N-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13043
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Expression Region
E2-F487
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Protein Length
Partial
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MST1, also known as STK4, is a serine/threonine kinase that plays a crucial role in various cellular processes, including apoptosis, cell proliferation, and immune response. As a key component of the Hippo signaling pathway, MST1 is involved in regulating organ size and tissue growth by controlling cell division and promoting apoptosis in excess cells. Dysregulation of MST1 has been associated with various diseases, including cancer, where its reduced activity can lead to unchecked cell proliferation. Additionally, MST1 is implicated in the regulation of immune cell function and response, making it a potential therapeutic target in immunological disorders. Research on recombinant MST1/STK4 protein is essential for understanding its functional roles and mechanisms in cellular signaling pathways. By producing and studying this protein, scientists can dissect its interactions with other signaling molecules and further explore its potential as a target for drug development. The structure and activity of MST1 can be analyzed using various biochemical techniques, promoting the understanding of its role in health and disease. Overall, the investigation of MST1/STK4 recombinant protein contributes to a broader understanding of kinase signaling, cellular regulation, and the development of novel therapeutic strategies for diseases linked to its dysfunction.
