Analytical Data
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基因名
DGKA
- Application
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别名
80KDA diacylglycerol kinase Diglyceride kinase alpha
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23743
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表达区间
1-735aa
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分子量
86.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DGKA (Diacylglycerol kinase alpha) is an important enzyme that plays a crucial role in lipid metabolism and cell signaling by converting diacylglycerol (DAG) to phosphatidic acid (PA). The balance between these two lipid molecules is vital for regulating various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of DGKA has been implicated in several diseases, such as cancer, cardiovascular disorders, and neurological conditions, making it a potential therapeutic target. Research on recombinantly expressed DGKA proteins is essential for understanding its structure-function relationships, mechanism of action, and interaction with other signaling molecules. Advances in recombinant DNA technology and protein expression systems have enabled the production of DGKA in various host organisms, allowing for detailed biochemical analyses and the development of high-throughput screening assays for potential DGKA inhibitors. This research not only enhances our understanding of DGKA's role in cellular signaling pathways but also paves the way for the discovery of novel therapeutics that could modulate DGKA activity and address related diseases.
