Analytical Data
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基因名
MAP4K6
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简介
MAP4K6 protein is a key serine/threonine kinase that negatively regulates Ras-related Rap2-mediated signaling, affecting neuronal structure and AMPA receptor trafficking. Its importance is underlined by its important role in regulating synaptic density, dendritic complexity, and surface AMPA receptor expression in hippocampal neurons. MAP4K6 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K6 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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别名
MINK1; Misshapen-like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
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种属
Human
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表达系统
Baculovirus
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N4C8
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表达区间
M1-G314
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP4K6, a member of the Mitogen-Activated Protein Kinase Kinase Kinase (MAP3K) family, plays a crucial role in various cellular processes, including stress response, cell proliferation, and differentiation. Recent studies have highlighted its involvement in the phosphorylation of downstream MAPK pathways, particularly in the context of cellular signaling and tumorigenesis. Dysregulation of MAP4K6 has been implicated in multiple diseases, notably cancer, where it can influence cellular behavior and contribute to tumor growth and metastasis. Researchers are increasingly focused on understanding the molecular mechanisms governing MAP4K6 activity and regulation, as well as its potential as a therapeutic target. The recombinant expression of MAP4K6 has garnered attention for its potential to elucidate its functional roles in cellular pathways and to screen for small-molecule inhibitors that could modulate its activity. Advanced studies exploring the structure-function relationship of MAP4K6 are vital for developing targeted therapies aimed at diseases linked to its aberrant signaling.
