Analytical Data
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Gene name
LTK
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简介
LTK protein, a tyrosine-protein kinase activated by ALKAL1 or ALKAL2 ligands, transduces signals, initiating the MAPK pathway upon ligand binding. It phosphorylates mainly the first tyrosine in the Y-x-x-x-Y-Y motif, with roles in promoting neurite outgrowth, cell survival, and regulating the secretory pathway, impacting ERESs and ER to Golgi transport. LTK Protein, Human (sf9, GST) is the recombinant human-derived LTK protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
LTK; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29376
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Expression Region
K450-S864
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Protein Length
Cytoplasmic Domain
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The LTK (Leukocyte Tyrosine Kinase) protein is a member of the receptor tyrosine kinase family, playing a significant role in cellular signaling pathways that regulate various physiological processes, including cell growth, differentiation, and apoptosis. LTK is predominantly expressed in immune cells, and its dysregulation has been implicated in various diseases, including autoimmune disorders and cancers. Research into LTK has gained momentum due to its potential as a therapeutic target; understanding its structural and functional properties could lead to innovative treatments. Recent studies have focused on the molecular mechanisms by which LTK influences immune responses, and how its pathway interacts with other signaling networks. Moreover, the identification of specific inhibitors of LTK could pave the way for novel interventions in conditions where LTK is aberrantly expressed. Investigating the interplay between LTK and other cellular components is crucial for unraveling its contribution to disease states and could ultimately facilitate the development of targeted therapies aimed at modulating LTK activity, thus enhancing therapeutic strategies in immunology and oncology.
