Analytical Data
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Gene name
MAK
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简介
MAK Protein, vital for ciliary length regulation, ensures photoreceptor survival by phosphorylating FZR1 in a cell cycle-dependent manner. It coactivates AR transcription and potentially aids spermatogenesis, with a possible role in maintaining chromosomal stability in prostate cancer cells. MAK Protein, Human (sf9, His, GST) is the recombinant human-derived MAK protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.
- Application
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Alternative Names
MAK; Serine/threonine-protein kinase MAK; Male germ cell-associated kinase
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Species
Human
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Source
Baculovirus
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Tag
N-8*His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20794
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Expression Region
N2-R623
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAK (Male-specific Locus on the Y chromosome, Also Known as "MAK-encoded Protein") is a protein that has garnered attention in recent years due to its potential implications in reproductive biology and immunology. The MAK gene is located on the Y chromosome and is primarily expressed in the testis, playing a significant role in spermatogenesis. Research has indicated that mutations or dysregulation of the MAK gene can lead to infertility issues in males, making it a crucial target for understanding male reproductive health. Furthermore, studies have suggested that MAK may also be involved in various cellular processes, including cell signaling and apoptosis, which could have broader implications in disease contexts, such as cancer. The recombinant expression of MAK protein in laboratory settings has enabled scientists to explore its structure-function relationships and potential therapeutic applications, allowing for a deeper understanding of its biological role. As the field of reproductive medicine advances, the study of MAK and its encoded protein may reveal novel insights into male infertility treatments and contribute to developing targeted interventions for men facing reproductive challenges. This line of research underscores the importance of unraveling genetic factors that impact fertility, establishing MAK as a significant focus within the broader context of male health and disease.
