Analytical Data
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基因名
MOG
- Application
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别名
Myelin-oligodendrocyte glycoprotein; Mog; MOGIG2
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种属
Mouse
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q61885
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表达区间
G29-T156
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分子量
21-25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Myelin oligodendrocyte glycoprotein (MOG) is a vital component of the myelin sheath in the central nervous system, playing a crucial role in maintaining the integrity of the myelin and facilitating communication between neurons. Research on MOG has gained significant attention due to its involvement in demyelinating diseases, particularly multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM). In these conditions, the immune system erroneously targets MOG, leading to inflammation and myelin damage, which ultimately disrupts neural signaling. The study of MOG-derived recombinant proteins has become increasingly important as they serve as valuable tools for understanding the mechanisms underlying autoimmune responses and for developing targeted therapies. These recombinant proteins are also instrumental in creating reliable animal models for studying demyelination and in evaluating potential treatments. Furthermore, the exploration of MOG-specific antibodies has opened up new avenues for diagnostic approaches, potentially enabling earlier detection and stratification of patients with demyelinating conditions. Overall, the research on MOG and its recombinant forms is critical in advancing our understanding of neuroinflammatory diseases and finding effective therapeutic strategies to ameliorate their impact.
