Analytical Data
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基因名
IL-2RB&IL-2RG
- Application
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别名
Il2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122
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种属
Mouse
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表达系统
HEK293
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标签
C-Avi;C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16297-1 (A27-E240)&P34902
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表达区间
P16297-1 (A27-E240)&P34902 (W23-A263)
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分子量
65-80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-2 (IL-2) is a crucial cytokine involved in the regulation of immune responses, particularly in T-cell proliferation and differentiation. The receptor for IL-2 consists of three subunits: IL-2Rα (CD25), IL-2Rβ (CD122), and IL-2Rγ (CD132), with IL-2Rβ (IL-2RB) and IL-2Rγ (IL-2RG) being essential for high-affinity binding and signaling. Research on recombinant forms of IL-2RB and IL-2RG has gained importance due to their roles in various immune-related disorders and therapeutic applications, including cancer immunotherapy and treatment of autoimmune diseases. Understanding the structure, function, and signaling pathways of these receptor components can provide insights into their involvement in disease mechanisms and potential as therapeutic targets. Moreover, recombinant proteins of IL-2RB and IL-2RG can be used to study receptor dynamics, facilitate drug development, and enhance the efficacy of IL-2-based therapies. As scientists explore the complexities of the IL-2 signaling pathway, the development of these recombinant proteins may lead to innovative strategies for modulating immune responses and improving clinical outcomes in patients with immune deficiencies or malignancies.
