Analytical Data
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Gene name
ZYX
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简介
ZYX protein is a focal adhesion protein that binds α-actin and CRP to target TES and ENA/VASP to focal adhesions to form actin-rich structures. It may play a crucial role in adhesion-stimulated gene expression. ZYX Protein, Human (HEK293, His) is the recombinant human-derived ZYX protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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Alternative Names
ZYX; Zyxin; Zyxin-2
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Species
Human
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Source
HEK293
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15942
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Expression Region
A2-T572
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AA Sequence
AAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
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Protein Length
Full Length of Mature Protein
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Molecular Weight
65.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of ZYX recombinant protein is rooted in the essential role of Zyxin, a focal adhesion-associated protein that participates in the regulation of cell adhesion, migration, and mechanotransduction. Zyxin is particularly important in the context of cellular responses to mechanical stress and extracellular matrix signaling, making it a crucial factor in various physiological and pathological processes, including tissue repair, cancer metastasis, and cardiovascular diseases. Researchers have identified that the interaction of Zyxin with other proteins and its localization at sites of cell adhesion highlight its functional importance in cytoskeletal dynamics. By producing ZYX recombinant protein, scientists aim to enhance our understanding of Zyxin's molecular mechanisms and its interaction networks, ultimately offering insights that can facilitate the development of therapeutic strategies targeting diseases where cell adhesion and migration play critical roles. Moreover, studying the structural and functional characteristics of the ZYX recombinant protein can provide a platform for exploring its potential as a biomarker or as a therapeutic target in regenerative medicine and oncology. As the interest in precision medicine and targeted therapies grows, ZYX represents a promising avenue for advancing our knowledge of cell signaling pathways and their implications in human health.
