Analytical Data
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基因名
IL-7 RA & IL-2 RG
- Application
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别名
IL-7 R alpha & IL-2 R gamma; IL-7 RA & IL-2 RG
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16871-1 (E21-D239)&P31785-1
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表达区间
P16871-1 (E21-D239)&P31785-1 (L23-N254)
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分子量
43-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-7 receptor alpha (IL-7Rα) and interleukin-2 receptor gamma (IL-2Rγ) are crucial components of the immune system, playing significant roles in lymphocyte development and function. IL-7Rα primarily mediates the effects of interleukin-7 (IL-7), a cytokine essential for T-cell development and survival, while IL-2Rγ is a shared component of several cytokine receptors, including those for interleukins 2, 4, 7, 9, and 15, which are vital for T-cell proliferation and differentiation. Dysregulation of these receptors is linked to various immune disorders, including autoimmune diseases and cancers, making them attractive targets for therapeutic interventions. Recent studies have focused on recombinant proteins of IL-7Rα and IL-2Rγ to better understand their signaling mechanisms and potential in modulating immune responses. These recombinant proteins can be utilized in a variety of experimental settings, including functional assays, therapeutic applications, and structural biology studies, to elucidate their roles in immunity and identify novel therapeutic strategies. The exploration of IL-7Rα and IL-2Rγ recombinant proteins promises to deepen our understanding of immune system regulation and to pave the way for innovative treatments for immunological disorders.
