Analytical Data
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基因名
SYNGAP1
- Application
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别名
Neuronal RasGAP (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (KIAA1938)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96PV0
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表达区间
1161-1343aa
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分子量
25.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYNGAP1 is a gene located on chromosome 6 that encodes a protein involved in synaptic signaling and plasticity in the brain. Mutations in SYNGAP1 have been linked to a range of neurodevelopmental disorders, including intellectual disability and epilepsy. Research has shown that the SYNGAP1 protein plays a critical role in regulating synaptic strength and contributes to cognitive functions. As the understanding of SYNGAP1's role in neural circuitry deepens, there is a growing interest in developing therapeutic interventions that target SYNGAP1-related pathways. The production and study of recombinant SYNGAP1 protein are crucial for elucidating its molecular mechanisms and interactions within neuronal systems. By generating and characterizing recombinant SYNGAP1, scientists aim to investigate its structural properties, binding interactions, and functional impacts on neurodevelopment and synaptic behavior. This research not only enhances our understanding of the pathophysiology associated with SYNGAP1 mutations but also paves the way for potential therapeutic strategies aimed at ameliorating the cognitive and behavioral deficits observed in affected individuals.
