Analytical Data
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Gene name
DPYSL3
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简介
The DPYSL3 protein plays a key role in class 3 semaphorin-triggered signaling, driving cytoskeletal remodeling that is critical for axon guidance, growth cone collapse, and cell migration. As a component of homo- and heterotetramers of CRMP1, DPYSL2, DPYSL4 or DPYSL5, it is intricately associated with related proteins, highlighting its involvement in complex cellular dynamics. DPYSL3 Protein, Human (His) is the recombinant human-derived DPYSL3 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14195
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Expression Region
M1-S570
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AA Sequence
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS
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Protein Length
Full Length
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Molecular Weight
66.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DPYSL3 (Developmental Plasminogen Activator Protein 3) has gained significant attention in recent years due to its pivotal role in neuronal development and its implications in various neurological disorders. This protein belongs to the collapsin response mediator protein (CRMP) family, which is known to regulate axon guidance and neuronal differentiation during embryonic development. Research has shown that DPYSL3 is crucial for neuronal polarity and plays a vital role in synaptic plasticity, potentially influencing learning and memory processes. Furthermore, alterations in DPYSL3 expression have been associated with neurodegenerative diseases, such as Alzheimer's disease and schizophrenia, highlighting its relevance in neurobiology and mental health. The study of recombinant DPYSL3 protein has opened avenues for understanding its molecular mechanisms and interactions within neuronal networks. By elucidating its structure and function, researchers aim to identify potential therapeutic targets and develop strategies for mitigating the effects of neurological disorders linked to DPYSL3 dysregulation. This research emphasizes the importance of understanding the molecular underpinnings of neuronal function and the potential for DPYSL3 as a biomarker or therapeutic target in neurodevelopmental and neurodegenerative diseases.
