Analytical Data
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Gene name
BRSK2
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简介
The BRSK2 protein is a serine/threonine protein kinase that plays a crucial role in cellular processes. BRSK2 is phosphorylated and activated by STK11/LKB1 and may coordinate cortical neuronal polarization through MAPT/TAU phosphorylation at “Thr-529” and “Ser-579”. BRSK2 Protein, Human (sf9, GST) is the recombinant human-derived BRSK2 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
BRSK2; Serine/threonine-protein kinase BRSK2; Brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; BR serine/threonine-protein kinase 2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IWQ3
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Expression Region
T2-P736
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRSK2 (Brahma Related Gene 1) is a serine/threonine kinase that plays a critical role in various cellular processes, including cell cycle regulation, neuronal differentiation, and metabolism. Its involvement in the AMP-activated protein kinase (AMPK) pathway highlights its significance in energy homeostasis and response to cellular stress. Recent studies have shown that dysregulation of BRSK2 is associated with several diseases, particularly neurodegenerative disorders and metabolic syndromes, making it a potential therapeutic target. The characterization of recombinant BRSK2 protein has become an important focus for understanding its structure-function relationship and the molecular mechanisms governing its activity. By producing and purifying BRSK2 in a recombinant system, researchers aim to elucidate its biological functions, interaction partners, and downstream signaling pathways. Additionally, the study of BRSK2 as a drug target paves the way for the development of novel therapeutics that could modulate its activity to treat diseases linked to its dysfunction. Overall, the investigation of BRSK2 not only enhances our comprehension of cellular signaling networks but also contributes significantly to the advancement of targeted therapies in the realm of metabolic and neurodegenerative disorders.
