Analytical Data
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基因名
Semaphorin-3A/SEMA3A
- Application
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别名
Semaphorin III; SEMA3A; SEMAD; Hsema-I; SEMA1; SemD; Semad; coll-1 ; Hsema-III; Sema III
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14563
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表达区间
K26-V771, R551A, R555A, R730A, K731A, R733A, R734A, R757A, R760A
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分子量
120-135 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Semaphorin-3A (SEMA3A) is a member of the semaphorin family of proteins, which are known to play crucial roles in axon guidance, neuronal development, and immune responses. Initially identified for its function in the nervous system, SEMA3A acts as a chemorepellent, guiding developing neurons by signaling through its receptor neuropilin-1 and plexin-A1. Recent studies have expanded our understanding of SEMA3A's multifaceted roles beyond neural development, revealing its involvement in various physiological processes, including cardiovascular development, tumor suppression, and immune modulation. Dysregulation of SEMA3A is associated with several pathological conditions, such as neurodegenerative diseases, cancer metastasis, and autoimmune disorders, highlighting its potential as a therapeutic target. The recombinant production of SEMA3A protein allows for detailed studies of its functional mechanisms and interactions within the cellular microenvironment. This research not only aids in elucidating the biological roles of SEMA3A but also presents opportunities for developing novel therapeutic strategies that leverage SEMA3A's signaling pathways to address various diseases. Understanding the structure-function relationship of recombinant SEMA3A is essential for optimizing its application in both basic research and clinical settings, especially for diseases where SEMA3A's signaling may be misregulated. Overall, SEMA3A represents a promising area of study with significant implications for neurobiology, immunology, and cancer research.
