Analytical Data
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Gene name
ITGB7
- Application
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Alternative Names
Integrin beta-7; ITGB7; Gut homing receptor beta subunit
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Species
Human
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Source
E. coli
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Tag
N-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P26010
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Expression Region
E20-H723
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AA Sequence
ELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADH
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Protein Length
Partial
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Molecular Weight
60-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ITGB7, or Integrin Beta 7, is a crucial component of the integrin family that plays a significant role in cell adhesion, migration, and immune response regulation. Its primary function is to form heterodimers with integrin alpha chains, primarily α4 and αE, facilitating interactions with extracellular matrix proteins and other cell types. This interaction is particularly important for lymphocyte trafficking and homing to specific tissues, making ITGB7 a target of interest in immunological research and therapy. Dysregulation of ITGB7 has been implicated in various pathological conditions, including inflammatory diseases and cancers, where aberrant cell adhesion and migration contribute to disease progression. Studies exploring the expression patterns of ITGB7 have shown its elevated levels in certain immune cell populations in inflammatory conditions, highlighting its potential as a biomarker for these diseases. Additionally, understanding the molecular mechanisms regulating ITGB7 expression and function could pave the way for novel therapeutic interventions aimed at modulating immune responses. Recent advancements in recombinant protein technology have enabled the production and characterization of ITGB7 proteins, providing valuable insights into their structural properties and interactions. These recombinant proteins can serve as essential tools for studying integrin biology, developing targeted therapies, and assessing the efficacy of new immunomodulatory strategies. Overall, research on ITGB7-recombinant proteins holds significant promise for advancing our understanding of immune regulation and addressing various immune-mediated disorders.
