Analytical Data
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Gene name
S/PROS1
- Application
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Alternative Names
Vitamin K-dependent protein S; PROS1; PROS
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P07225
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Expression Region
V284-S676
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Molecular Weight
53-60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of S/PROS1 recombinant protein is rooted in the exploration of its crucial role in the coagulation process and its potential implications in various physiological and pathological conditions. S-protein, also known as protein S, functions as a vitamin K-dependent plasma glycoprotein that acts as a cofactor to activated protein C, thereby playing a significant role in the regulation of coagulation by inactivating factors Va and VIIIa. Deficiencies or dysfunctions in protein S have been associated with an increased risk of thromboembolic disorders, including deep vein thrombosis and pulmonary embolism, making it a vital target for research in hematology and thrombosis. The recombinant production of S/PROS1 enables detailed studies of its structure-function relationships, affinity for phospholipid surfaces, and interactions with other coagulation factors. This research not only aids in better understanding the molecular mechanisms underlying clotting disorders but also paves the way for therapeutic innovations, such as the development of protein S analogs or derivatives that could help mitigate bleeding or thrombotic complications. Overall, the investigation of recombinant S/PROS1 aims to contribute significantly to both basic science and clinical applications in the field of hemostasis and vascular biology.
