Analytical Data
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基因名
S/PROS1
- Application
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别名
Vitamin K-dependent protein S; PROS1; PROS
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07225
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表达区间
V284-S676
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分子量
53-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of S/PROS1 recombinant protein is rooted in the exploration of its crucial role in the coagulation process and its potential implications in various physiological and pathological conditions. S-protein, also known as protein S, functions as a vitamin K-dependent plasma glycoprotein that acts as a cofactor to activated protein C, thereby playing a significant role in the regulation of coagulation by inactivating factors Va and VIIIa. Deficiencies or dysfunctions in protein S have been associated with an increased risk of thromboembolic disorders, including deep vein thrombosis and pulmonary embolism, making it a vital target for research in hematology and thrombosis. The recombinant production of S/PROS1 enables detailed studies of its structure-function relationships, affinity for phospholipid surfaces, and interactions with other coagulation factors. This research not only aids in better understanding the molecular mechanisms underlying clotting disorders but also paves the way for therapeutic innovations, such as the development of protein S analogs or derivatives that could help mitigate bleeding or thrombotic complications. Overall, the investigation of recombinant S/PROS1 aims to contribute significantly to both basic science and clinical applications in the field of hemostasis and vascular biology.
