Analytical Data
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Gene name
Podoplanin
- Application
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Alternative Names
Podoplanin; Aggrus; Glycoprotein 36; Gp36; PA2.26 Antigen; T1-Alpha; T1A; PDPN; GP36
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86YL7-1
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Expression Region
A23-L131
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Molecular Weight
60-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Podoplanin is a type I transmembrane glycoprotein that plays a crucial role in various physiological and pathological processes, particularly in lymphangiogenesis, tumor progression, and immune response modulation. Initially discovered as a marker for lymphatic endothelium, podoplanin is also expressed in various tissues and associated with several types of cancer, where it contributes to cancer cell migration, invasion, and metastasis. Its unique structural features, including an O-glycosylated mucin-like domain, facilitate interactions with specific receptors, such as C-type lectin receptors, influencing cell behavior and signaling pathways. Research into recombinant podoplanin protein has gained momentum due to its potential applications in diagnostic and therapeutic settings. As a target for cancer immunotherapy and a tool for studying lymphatic system biology, recombinant podoplanin can be utilized to develop novel vaccines or therapeutic agents aimed at modulating immune responses. Additionally, understanding the biochemical properties and functional roles of podoplanin through recombinant technology can provide insights into its mechanisms in tumor biology and lymphatic vessel development. Consequently, the study of podoplanin-focused recombinant proteins is integral to advancing cancer research and developing effective strategies for disease management.
