Analytical Data
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基因名
HLA-G
- Application
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别名
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
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种属
Human
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表达系统
E. coli
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17693-1
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表达区间
G25-A206
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分子量
23-26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-G is a unique class Ib human leukocyte antigen that plays a critical role in immune regulation, particularly in pregnancy and transplantation tolerance. Unlike classical HLA molecules, HLA-G is characterized by its restricted expression patterns and the ability to inhibit natural killer (NK) cell activity and T-cell responses, contributing to the protection of fetal tissues from maternal immune attack. The study of recombinant HLA-G protein has gained momentum due to its potential therapeutic applications in various clinical settings, including organ transplantation, autoimmune diseases, and cancer immunotherapy. Researchers are increasingly interested in understanding the structure-function relationship of HLA-G and its interactions with immune cells to harness its immunomodulatory properties. By producing HLA-G as a recombinant protein, scientists aim to investigate its biological functions, develop diagnostic tools, and explore its use as a biomarker for pregnancy complications and immune-related disorders. Additionally, recombinant HLA-G can be utilized in preclinical studies to evaluate its therapeutic potential, paving the way for innovative treatments aimed at enhancing immune tolerance and mitigating unwanted immune responses in diverse medical contexts.
