Analytical Data
-
Gene name
GAS6
-
简介
The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (400a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293, with N-His labeled tag.
- Application
-
Alternative Names
GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709
-
Species
Human
-
Source
HEK293
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q14393-2
-
Expression Region
D279-A678
-
Molecular Weight
45-50 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Gas6 (Growth arrest-specific 6) is a vitamin K-dependent protein that plays a crucial role in various biological processes, including cell survival, proliferation, and immune response regulation. Initially discovered for its involvement in cell growth arrest, Gas6 has garnered significant attention due to its multifaceted roles in pathology, particularly in cancer and cardiovascular diseases. It functions by binding to specific receptors, such as Axl, Tyro3, and Mer, which are part of the TAM receptor family, leading to the activation of downstream signaling pathways that influence cell behavior. Research has shown that dysregulation of Gas6 and its receptors is linked to tumor progression, metastasis, and the modulation of immune responses, making it a potential target for therapeutic intervention. Moreover, the recombinant production of Gas6 protein has enabled detailed biochemical studies and therapeutic applications, including the development of engineered proteins for targeted cancer therapy and immune modulation. Understanding the role of Gas6 through recombinant protein studies could provide novel insights into its mechanisms and offer innovative strategies for treating diseases associated with its dysregulation.
