Analytical Data
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基因名
Osteocrin
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简介
Osteocrin protein regulates dendritic growth in the developing cerebral cortex by inhibiting branching. It is induced in the brain upon membrane depolarization and binds to the natriuretic peptide receptor NPR3/NPR-C, preventing the interaction with natriuretic peptides and increasing cproduction. Osteocrin also interacts with NPR3, further modulating dendritic growth regulation. Osteocrin Protein, Human (His) is the recombinant human-derived Osteocrin protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Osteocrin; Musclin; OSTN
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61366
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表达区间
V28-G133
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蛋白长度
Full Length of Mature Protein
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分子量
12.0-13.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Osteocrin is a secreted protein primarily expressed in osteoblasts and has gained attention in recent years due to its potential role in bone remodeling and mineralization. It is closely associated with the extracellular matrix and interacts with various signaling pathways that regulate bone formation and homeostasis. Research has demonstrated that Osteocrin can modulate the activity of osteoblasts and osteoclasts, thereby influencing bone density and strength. Investigations into the recombinant form of Osteocrin have been propelled by its promising implications for treating bone-related disorders such as osteoporosis and fractures. Scientists have focused on the design and production of recombinant Osteocrin to assess its biochemical properties, biological activity, and therapeutic potential. Moreover, studies have explored its mechanisms of action, including its engagement with other cellular receptors and signaling molecules involved in the bone remodeling process. Understanding and harnessing the functionalities of recombinant Osteocrin could pave the way for innovative therapeutic strategies aimed at enhancing bone health and mitigating the impacts of degenerative bone diseases.
