Analytical Data
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Gene name
YKT6
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简介
YKT6 is a vesicle soluble NSF attachment protein receptor (v-SNARE) that mediates vesicle docking and fusion in the endoplasmic reticulum to Golgi trafficking, forming a SNARE complex with GOSR1, GOSR2, and STX5. It is also involved in the transport of early/recycling endosomes to the trans-Golgi network, forming another SNARE complex with BET1L, GOSR1 and STX5. YKT6 Protein, Human (His) is the recombinant human-derived YKT6 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Synaptobrevin homolog YKT6; YKT6
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O15498-1
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Expression Region
M1-M198
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AA Sequence
MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM
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Protein Length
Full Length of Isoform-1
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Molecular Weight
28.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
YKT6 is a member of the Ypt/Rab family of small GTPases that plays a crucial role in intracellular vesicle trafficking and membrane fusion processes. Identified initially in yeast, YKT6 has garnered significant attention due to its conservation across various species, including humans, highlighting its fundamental role in cellular functions. Research into YKT6 has revealed its involvement in the regulation of exocytosis and endocytosis, processes essential for neurotransmitter release and cellular communication. Dysregulation of YKT6 has been implicated in various diseases, including neurodegenerative conditions and cancer, making it a potential therapeutic target. Recent studies have focused on elucidating its mechanistic pathways, interactions with other proteins, and the impact of post-translational modifications on its function. Understanding the structure and dynamics of YKT6 is vital for developing targeted interventions to correct its dysfunctional pathways, thus opening avenues for innovative treatment strategies in related disorders. As the field advances, detailed knowledge about YKT6's role in cellular contexts continues to emerge, emphasizing the protein's importance in maintaining cellular homeostasis and its potential implications in health and disease.
