Analytical Data
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Gene name
TSSK1
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简介
The TSSK1 protein is a testis-specific serine/threonine protein kinase that plays a crucial role during late spermatogenesis, especially during cytoplasmic remodeling. It phosphorylates "Ser-288" of TSKS, which contributes to the transition of the ring structure around the base of the flagellum. TSSK1 Protein, Human (sf9, GST) is the recombinant human-derived TSSK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
TSSK1B; Testis-specific serine/threonine-protein kinase 1; TSK-1; TSK1; TSSK-1; Testis-specific kinase 1; Serine/threonine-protein kinase 22A
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXA7
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Expression Region
D2-Q367
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TSSK1, or Testis Specific Serine Kinase 1, is a member of the testis-specific serine/threonine kinase family, which is primarily expressed in the testes and plays a critical role in spermatogenesis. Recent studies have highlighted its significance in male fertility, as it is involved in the regulation of sperm development and function. The dysfunctional expression of TSSK1 has been associated with various forms of infertility, making it a promising target for research in reproductive biology and potential therapeutic interventions. Additionally, TSSK1 has been implicated in cellular signaling pathways that govern cell division and differentiation, further establishing its biological importance. The production and characterization of recombinant TSSK1 protein have become essential for elucidating its function and mechanism of action, allowing researchers to investigate the protein's interactions with other molecular partners and its regulatory roles in reproductive cells. By studying the recombinant TSSK1, scientists aim to understand how alterations in its activity could lead to male infertility and may provide insights into developing diagnostic or therapeutic strategies aimed at male reproductive disorders. Overall, the research on TSSK1 recombinant protein not only sheds light on fundamental aspects of male reproduction but also has potential implications for advancing fertility treatments and understanding the complexities of reproductive health.
