Analytical Data
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Gene name
STX7
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简介
The STX7 protein plays a key role in protein trafficking and membrane fusion events. It guides proteins from the plasma membrane to early endosomes, facilitates homotypic fusion of endocytic organelles, and mediates transport from early endosomes to late endosomes and lysosomes. STX7 Protein, Human (HEK293, His) is the recombinant human-derived STX7 protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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Alternative Names
Syntaxin-7; STX7; syntaxin 7
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Species
Human
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Source
HEK293
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15400
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Expression Region
S2-L238
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AA Sequence
SYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTL
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Protein Length
Partial
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Molecular Weight
31-36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STX7 (Syntaxin 7) is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family, which plays a critical role in membrane trafficking and fusion processes within cells. Research into STX7 has gained significant interest due to its involvement in several fundamental cellular functions, including endosome-lysosome fusion, neurotransmitter release, and protein secretion. Mutations or dysregulation of STX7 have been implicated in various neurodegenerative diseases and genetic disorders, underscoring its importance in maintaining cellular homeostasis and function. Furthermore, STX7 is associated with the regulation of immune responses and has been shown to influence the trafficking of proteins involved in pathogen recognition and response. The recombinant expression of STX7 protein allows for in-depth studies into its structural and functional properties, enabling researchers to elucidate its specific roles in cellular mechanisms. This understanding may lead to the development of targeted therapeutics for diseases linked to STX7 dysfunction, highlighting the significance of this protein in both fundamental biology and clinical applications.
