Analytical Data
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Gene name
SLIT2
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简介
Slit2 is a key protein in cell migration and guides axonal navigation in neural development by interacting with detour cognate receptors. In the forebrain, Slit2 acts as a repulsive signal, preventing axons from incorrectly crossing the midline. SLIT2 Protein, Human (208a.a, HEK293, His) is the recombinant human-derived SLIT2 protein, expressed by HEK293, with C-His labeled tag.
- Application
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Alternative Names
SLIT2 ; Slit homolog 2 protein ; SLIL3 ; Slit-2
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94813-1
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Expression Region
L271-S479
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Protein Length
Partial
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLIT2 (Slit homologue 2) is a crucial protein involved in various biological processes, including neuronal development, axon guidance, and the regulation of cellular migration. Initially identified for its role in the central nervous system, SLIT2 operates through its interaction with the Roundabout (Robo) receptor family, facilitating the repulsion of growth cones during neuronal development. Beyond its neurodevelopmental functions, SLIT2 has garnered attention for its involvement in cancer biology, where it may act as a tumor suppressor by inhibiting tumor cell invasion and metastasis. Research has indicated that SLIT2 can influence signaling pathways related to cell proliferation and angiogenesis, presenting potential therapeutic implications in oncology. Furthermore, understanding the molecular mechanisms underlying SLIT2's actions could pave the way for innovative treatments targeting SLIT2-Robo signaling in various diseases. Recombinant SLIT2 protein has been generated for investigative purposes, allowing scientists to explore its effects on different cell types and elucidate its role in cellular communication and tumor dynamics. As ongoing studies continue to reveal the multifaceted functions of SLIT2, it emerges as a promising candidate for therapeutic interventions aimed at modulating its signaling pathways to improve outcomes in neurodegenerative disorders and cancer therapies.
