Analytical Data
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Gene name
ADAR1
- Application
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Alternative Names
136 kDa double-stranded RNA-binding protein (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) (ADAR1) (DSRAD) (G1P1) (IFI4) (DRADA)
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55265
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Expression Region
1-176aa
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Molecular Weight
47.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAR1 (Adenosine Deaminase Acting on RNA 1) is a crucial enzyme that plays a significant role in RNA editing by converting adenosine residues to inosine in double-stranded RNA. This post-transcriptional modification is essential for various cellular processes, including RNA stability, viral defense, and the regulation of gene expression. The dysregulation of ADAR1 has been implicated in several diseases, including autoimmune disorders, neurodegenerative diseases, and cancers, as it can influence the immune response and promote tumorigenesis through aberrant RNA editing. Recent studies have highlighted the importance of ADAR1 in modulating innate immune pathways, particularly its involvement in the recognition of viral RNA and the subsequent activation of immune responses. Additionally, ADAR1 has been shown to interact with various cellular factors and pathways, making it a pivotal component in maintaining cellular homeostasis. The research on ADAR1 has gained momentum, focusing on its potential as a therapeutic target, where manipulating its activity could enhance antiviral responses or restore normal RNA editing in pathologies associated with its dysfunction. Understanding the complex mechanisms underlying ADAR1 function and its role in disease could pave the way for novel therapeutic strategies and improve our comprehension of RNA biology.
