Cat: IPD-X37721

Recombinant Mouse HLTF Protein,His

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Analytical Data

  • 基因名

    HLTF

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1; Sucrose nonfermenting protein 2-like 3; RING finger protein 80; DNA-binding protein/plasminogen activator inhibitor 1 regulator

  • 种属

    Mouse

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 95% as determined by SDS-PAGE.

  • 蛋白编号

    Q6PCN7

  • 表达区间

    Ala831~Lys990

  • 分子量

    21kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

HLTF (Helicase-Like Transcription Factor) is a critical member of the SWI/SNF family of ATP-dependent chromatin remodeling complexes, playing essential roles in DNA repair, replication, and transcriptional regulation. Research into HLTF has intensified due to its involvement in various cellular processes and its potential implications in cancer biology. Notably, HLTF has been implicated in the repair of DNA double-strand breaks through homologous recombination, which is a vital mechanism for maintaining genomic integrity. Its dysfunction has been linked to increased genomic instability, a hallmark of many cancers. Furthermore, HLTF interacts with a variety of proteins that are essential for cell cycle regulation, apoptosis, and response to DNA damage, making it a pivotal factor in cell survival and proliferation. Investigating HLTF as a recombinant protein has opened avenues for understanding its biochemical properties and functional mechanisms in greater detail. The ability to produce HLTF in a laboratory setting facilitates the development of assays to study its helicase activity, protein interactions, and structural dynamics, all of which are crucial for elucidating its role in health and disease. As research progresses, HLTF presents exciting opportunities for therapeutic interventions in cancer and genetic disorders linked to defective DNA repair pathways.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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