Analytical Data
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Gene name
HLTF
- Application
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Alternative Names
HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1; Sucrose nonfermenting protein 2-like 3; RING finger protein 80; DNA-binding protein/plasminogen activator inhibitor 1 regulator
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q14527
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Expression Region
Ala837~Lys996
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HLTF (Helicase-Like Transcription Factor) is a critical member of the SWI/SNF family of ATP-dependent chromatin remodeling complexes, playing essential roles in DNA repair, replication, and transcriptional regulation. Research into HLTF has intensified due to its involvement in various cellular processes and its potential implications in cancer biology. Notably, HLTF has been implicated in the repair of DNA double-strand breaks through homologous recombination, which is a vital mechanism for maintaining genomic integrity. Its dysfunction has been linked to increased genomic instability, a hallmark of many cancers. Furthermore, HLTF interacts with a variety of proteins that are essential for cell cycle regulation, apoptosis, and response to DNA damage, making it a pivotal factor in cell survival and proliferation. Investigating HLTF as a recombinant protein has opened avenues for understanding its biochemical properties and functional mechanisms in greater detail. The ability to produce HLTF in a laboratory setting facilitates the development of assays to study its helicase activity, protein interactions, and structural dynamics, all of which are crucial for elucidating its role in health and disease. As research progresses, HLTF presents exciting opportunities for therapeutic interventions in cancer and genetic disorders linked to defective DNA repair pathways.
