Analytical Data
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基因名
TMEM119
- Application
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别名
Osteoblast induction factor (OBIF)
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种属
Human
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表达系统
HEK293
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标签
C- hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q4V9L6
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表达区间
26–96aa
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分子量
36.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM119 is a transmembrane protein primarily expressed in microglia, the resident immune cells of the central nervous system (CNS). Its role in microglial biology has garnered significant attention due to its potential implications in neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. Research has indicated that TMEM119 is involved in the regulation of microglial homeostasis, activation, and response to injury. Its unique expression pattern makes TMEM119 a promising marker for studying microglial activation states and the role of these cells in neuroinflammatory processes. Scientists have sought to produce recombinant TMEM119 protein to facilitate the investigation of its structure-function relationships, interactions with other proteins, and its signaling pathways within microglia. Additionally, understanding the functional properties of TMEM119 could provide insights into how microglia contribute to the pathology of various neurological disorders and could potentially unveil new therapeutic targets for intervention. Overall, the study of TMEM119 recombinant protein represents a crucial step in elucidating the complex roles of microglia in health and disease.
