Analytical Data
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基因名
CGREF1
- Application
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别名
rHuCell growth regulator with EF hand domain protein 1/CGREF1, His; Cell Growth Regulator with EF Hand Domain Protein 1; Cell Growth Regulatory Gene 11 Protein; Hydrophobestin; CGREF1; CGR11
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
A0A4W8VYG7
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表达区间
A20-I301
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氨基酸序列
APKDGVTRPDSEVQHQLLPNPFQPGQEQLGLLQSYLKGLGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI
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蛋白长度
Partial
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分子量
29-42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tubby proteins are a family of evolutionarily conserved proteins that play critical roles in various biological processes, including cell signaling, energy homeostasis, and neuronal function. Initially identified in the context of obesity and diabetes, mutations in the Tubby gene have been linked to phenotypes such as increased adiposity and neurological impairments. Research has revealed that Tubby proteins function as adaptors in intracellular signaling pathways, facilitating the transport of specific cellular signals from the plasma membrane to the nucleus. This transport is crucial for the regulation of gene expression related to metabolic and neural functions. Given their significant roles in cellular communication and metabolic regulation, Tubby proteins have garnered attention for their potential therapeutic implications in obesity-related disorders and neurodegenerative diseases. Studies focusing on the structural characteristics and functional mechanisms of Tubby proteins aim to elucidate how they interact with various signaling molecules and participate in the modulation of biochemical pathways. Understanding these mechanisms may unveil new targets for drug development and therapeutic strategies addressing metabolic diseases and neurological conditions associated with Tubby protein dysfunction. As research progresses, the study of Tubby proteins continues to expand, revealing their multifaceted roles in health and disease.
