Analytical Data
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Gene name
SP-17
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简介
The SP-17 protein is an important sperm surface-binding protein that promotes high-affinity sperm attachment to the zona pellucida, indicating its critical role in fertilization. It is involved in the binding of the zona pellucida and carbohydrates, emphasizing its importance in the fertilization process. SP-17 Protein, Human (His) is the recombinant human-derived SP-17 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Sperm surface protein Sp17; CT22; Sp17-1; Sperm protein 17; SPA17;
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Species
Human
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Source
E. coli
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15506
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Expression Region
M1-K151
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Protein Length
Full Length
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Molecular Weight
20-28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SP-17 protein, derived from the sperm of certain species, has garnered significant attention in the field of reproductive biology and immunology due to its unique characteristics and potential applications. Research indicates that SP-17 plays a critical role in sperm-egg interaction and fertilization processes, acting as a crucial factor in maintaining sperm motility and function. Furthermore, studies have proposed its involvement in immune modulation, raising interest in its potential as a target for contraceptive development and immunotherapies. The protein exhibits a distinctive expression pattern in sperm and has been associated with various fertility-related disorders. Investigating the biochemical properties, structural biology, and functional mechanisms of SP-17 can provide insights into male fertility and the complexities of reproductive immunology. Additionally, as an emerging candidate for vaccine development, SP-17 may offer innovative avenues for addressing both infertility issues and managing autoimmune responses. The ongoing research into SP-17 aims not only to elucidate its biological significance but also to explore its therapeutic potential, making it a compelling subject in the intersection of reproductive health and molecular biology.
