Analytical Data
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基因名
MD-2/LY96
- Application
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别名
ESOP-1 (Protein MD-2) (Ly-96) (ESOP1) (MD2)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6Y9
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表达区间
19-160aa
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分子量
20.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MD-2, also known as LY96, is a key accessory protein that plays a crucial role in the innate immune response by forming a complex with Toll-like receptor 4 (TLR4). This complex is essential for the recognition of lipopolysaccharides (LPS), which are components of the outer membrane of Gram-negative bacteria. When LPS binds to the MD-2/TLR4 complex, it triggers a cascade of signaling pathways that lead to the activation of immune cells, culminating in the production of pro-inflammatory cytokines. Understanding MD-2/LY96 is vital for elucidating the mechanisms of sepsis and other inflammatory diseases, as it could pave the way for novel therapeutic interventions. Research has shown that variations in the MD-2 gene can affect susceptibility to infections and the inflammatory response, making it an important target for study. Additionally, recombinant MD-2 protein has been utilized in various experimental settings to explore its structure-function relationships and to develop potential inhibitors that could modulate TLR4 signaling. The ongoing investigation into MD-2/LY96 not only enhances our understanding of immune system dynamics but also contributes to the development of strategies for treating bacterial infections and related inflammatory conditions.
