Analytical Data
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基因名
CK2 alpha/CSNK2A1
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简介
The CK2 α/CSNK2A1 protein is a constitutively active kinase that phosphorylates substrates and regulates cell cycle, apoptosis, transcription, and viral infection. CK2 α/CSNK2A1 also regulates the cellular clock, Wnt signaling, modulates extracellular proteins, and plays a role in viral infection. CK2 alpha/CSNK2A1 Protein, Mouse (sf9) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells, with tag free.
- Application
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别名
Casein kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1
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种属
Mouse
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q60737
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表达区间
Q60737 (N-G&P, M1-Q391)
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蛋白长度
Full Length
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK2 alpha, also known as CSNK2A1, is a pivotal serine/threonine kinase involved in various cellular processes, including cell proliferation, survival, and differentiation. This enzyme operates as a tetrameric protein complex, consisting of two catalytic subunits (alpha) and two regulatory subunits (beta), enabling its diverse regulatory functions. The dysregulation of CK2 alpha activity has been implicated in several malignancies, highlighting its potential as a therapeutic target in cancer treatment. Research has recently focused on the generation of recombinant CK2 alpha proteins to facilitate the study of its biochemical properties, substrate specificity, and interaction with other cellular proteins. By utilizing techniques such as molecular cloning and protein expression systems, researchers can obtain high-purity CK2 alpha for in vitro assays and drug screening. Understanding the structure-function relationship of CK2 alpha through recombinant protein studies could elucidate its role in oncogenesis and lead to the development of specific inhibitors, enhancing the therapeutic arsenal against CK2-related cancers. Furthermore, KS2A1's involvement in other cellular pathways, such as DNA damage response and circadian rhythms, underscores the importance of these studies in contributing to a broader understanding of CK2's biological significance.
