Analytical Data
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Gene name
APLP-2
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简介
APLP-2, potentially involved in hemostasis regulation, exhibits inhibitory effects on coagulation factors. Its soluble form may interact with G-protein signaling pathways and bind to DNA. APLP-2 inhibits various proteases and modulates the nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains. It interacts with proteins like CPEB1, DAB2, APBB2/FE65L, and APBB3/FE65L2, suggesting diverse cellular roles. APLP-2 Protein, Human (HEK293, His) is the recombinant human-derived APLP-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
APPH; CDEBP; CDEI box-binding; APPL2; YWK-II;
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q06481-1
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Expression Region
G32-S692
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Protein Length
Extracellular Domain
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Molecular Weight
85-100 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APLP-2 (Amyloid Precursor-Like Protein 2) is a member of the amyloid precursor protein (APP) family, which has garnered attention due to its potential roles in neurobiology and disease. The protein is involved in various cellular processes, including cell adhesion, signaling, and neuronal development. Research has highlighted its association with Alzheimer's disease, given its structural similarities to APP and its role in the production of amyloid-beta peptides. However, unlike APP, the physiological roles of APLP-2 remain less understood. Studies suggest that APLP-2 may have neuroprotective functions and influence synaptic plasticity, which are vital for cognitive processes. The recombinant expression of APLP-2 allows for detailed investigations into its biochemical properties and interactions, providing insights into its functional significance in the nervous system. Understanding the mechanisms through which APLP-2 operates could reveal novel therapeutic targets for neurodegenerative diseases. As research progresses, recombinant APLP-2 protein is being utilized in various experimental models to elucidate its role in neuronal health and pathology, paving the way for potential applications in enhancing brain function and developing treatments for related disorders.
