Analytical Data
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基因名
APLP-2
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简介
APLP-2, potentially involved in hemostasis regulation, exhibits inhibitory effects on coagulation factors. Its soluble form may interact with G-protein signaling pathways and bind to DNA. APLP-2 inhibits various proteases and modulates the nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains. It interacts with proteins like CPEB1, DAB2, APBB2/FE65L, and APBB3/FE65L2, suggesting diverse cellular roles. APLP-2 Protein, Human (HEK293, His) is the recombinant human-derived APLP-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
APPH; CDEBP; CDEI box-binding; APPL2; YWK-II;
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06481-1
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表达区间
G32-S692
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蛋白长度
Extracellular Domain
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分子量
85-100 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APLP-2 (Amyloid Precursor-Like Protein 2) is a member of the amyloid precursor protein (APP) family, which has garnered attention due to its potential roles in neurobiology and disease. The protein is involved in various cellular processes, including cell adhesion, signaling, and neuronal development. Research has highlighted its association with Alzheimer's disease, given its structural similarities to APP and its role in the production of amyloid-beta peptides. However, unlike APP, the physiological roles of APLP-2 remain less understood. Studies suggest that APLP-2 may have neuroprotective functions and influence synaptic plasticity, which are vital for cognitive processes. The recombinant expression of APLP-2 allows for detailed investigations into its biochemical properties and interactions, providing insights into its functional significance in the nervous system. Understanding the mechanisms through which APLP-2 operates could reveal novel therapeutic targets for neurodegenerative diseases. As research progresses, recombinant APLP-2 protein is being utilized in various experimental models to elucidate its role in neuronal health and pathology, paving the way for potential applications in enhancing brain function and developing treatments for related disorders.
