Analytical Data
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基因名
SLC22A6
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简介
The SLC22A6 protein acts as a Na(+)-independent organic anion (OA)/dicarboxylic acid antiporter and promotes renal elimination by transporting OA from proximal tubule cells into the urine. It transports coenzymes (BH4, BH2, septopterin) and determines blood biopterin levels as well as prostaglandins, cyclic nucleotides, tryptophan metabolites, uremic toxins (e.g. indoxyl sulfate) and xenobiotics (e.g. ochratoxin). SLC22A6 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC22A6 protein, expressed by Sf9 insect cells .
- Application
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别名
SLC22A6; Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; Hroat1
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种属
Human
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表达系统
HEK293
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标签
N-His;C-Flag;N-MBP
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q4U2R8-1
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表达区间
A2-L563
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC22A6, also known as Organic Anion Transporter 1 (OAT1), plays a crucial role in the renal excretion of various endogenous and exogenous organic anions, including drugs and metabolic waste products. This transporter is pivotal in pharmacokinetics, influencing drug efficacy and toxicity by modulating the clearance of therapeutic agents from the bloodstream. Mutations or polymorphisms in the SLC22A6 gene can lead to altered transporter function, potentially affecting individual drug response and susceptibility to adverse effects. Given its significance in drug metabolism, researchers have focused on characterizing the SLC22A6 protein to better understand its transport mechanisms, substrate specificity, and regulatory pathways. Additionally, recombinant SLC22A6 protein production enables the investigation of its interactions with various ligands and drugs in vitro, aiding in the elucidation of structure-function relationships. This research also has implications for personalized medicine, as insights gained from SLC22A6 studies may contribute to the optimization of drug dosing regimens based on genetic profiling. Furthermore, the investigation of SLC22A6 is vital for understanding its role in kidney function and disease, as well as developing strategies to mitigate drug-drug interactions that may arise from competition for transport pathways. Overall, the comprehensive study of SLC22A6 as a recombinant protein is essential for advancing our knowledge in pharmacology, toxicology, and clinical therapeutics.
