Analytical Data
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基因名
UAP1
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简介
UAP1 protein functions as an enzyme that catalyzes the conversion of UTP and GlcNAc-1-P into UDP-GlcNAc, as well as UTP and GalNAc-1-P into UDP-GalNAc. Notably, isoform AGX1 exhibits 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 displays 8 times more activity towards GlcNAc-1-P, highlighting distinct substrate preferences between the isoforms. UAP1 Protein, Human (P.pastoris, His) is the recombinant human-derived UAP1 protein, expressed by P. pastoris , with N-His labeled tag.
- Application
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别名
AGX 1; AGX-2; AGX1; Antigen X; AntigenX; SPAG 2; SPAG2; Sperm associated antigen 2; Sperm-associated antigen 2; UAP 1; uap1
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种属
Human
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表达系统
P. pastoris
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16222
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表达区间
M1-I522
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氨基酸序列
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UAP1 (Ubiquitin-Activating Enzyme 1) is a critical enzyme involved in the ubiquitin-proteasome system, which plays a pivotal role in regulating protein degradation and turnover within the cell. The research surrounding UAP1 recombinant proteins has gained significant traction due to their potential implications in various biological processes, including cell cycle regulation, DNA repair, and signal transduction. Abnormalities in ubiquitination pathways have been linked to numerous diseases, including cancer, neurodegenerative disorders, and infections, highlighting the importance of understanding UAP1's functional mechanisms. By producing recombinant UAP1 proteins, researchers aim to elucidate the enzyme's structural properties and interaction dynamics with ubiquitin and other substrates. This can provide deeper insights into the regulatory functions of UAP1 and its role in disease pathology. Additionally, the availability of recombinant UAP1 facilitates the exploration of potential therapeutic interventions targeting the ubiquitin-proteasome system. As the field of proteomics continues to expand, the study of UAP1 and its recombinant variants is vital for advancing our comprehension of protein homeostasis and developing novel strategies for treating diseases linked to ubiquitin-related dysregulation.
