Analytical Data
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Gene name
CECR2
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简介
The CECR2 protein is a regulatory subunit in the CERF-1 and CERF-5 ISWI chromatin remodeling complexes that assembles ordered nucleosome arrays to help DNA enter replication, transcription, and repair. Despite lacking mononucleosome sliding ability, these complexes make crucial contributions to various developmental processes. CECR2 Protein, Human (His) is the recombinant human-derived CECR2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
CECR2; Cat eye syndrome critical region protein 2
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXF3
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Expression Region
R425-H538
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CECR2 (Cat Eye Syndrome Chromosome Region Candidate 2) is a protein that plays a significant role in developmental processes and cellular differentiation. It has been implicated in various biological functions, including chromatin remodeling and gene regulation, primarily in embryonic development. Mutations or dysregulation of CECR2 are associated with cat eye syndrome, a genetic condition characterized by a range of developmental abnormalities, particularly affecting the eyes and urinary tract. Recent studies have highlighted the importance of CECR2 in neuronal differentiation and its potential involvement in neurodevelopmental disorders. Research into CECR2 recombinant protein focuses on understanding its structural and functional properties, which could reveal insights into its role in cellular mechanisms and disease pathways. The production and characterization of CECR2 recombinant protein allow for detailed functional assays, enabling researchers to investigate its interactions with other cellular components and its effects on gene expression. This research has important implications for understanding the underlying mechanisms of diseases associated with CECR2 mutations and could lead to the development of novel therapeutic strategies targeting related pathways.
