Analytical Data
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基因名
BPTF
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简介
BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human (His) is the recombinant human-derived BPTF protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
BPTF; Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12830
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表达区间
D2865-A3033
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BPTF (bromodomain PHD finger transcription factor) is a multi-functional protein that plays a critical role in various cellular processes, including transcription regulation, chromatin remodeling, and stem cell maintenance. Its involvement in the pathology of several diseases, particularly cancer, has made it a significant target for research. BPTF is a component of the nucleosome remodeling and deacetylation (NuRD) complex, which is essential for altering chromatin states and regulating gene expression. Mutations or dysregulation of BPTF have been associated with tumorigenesis, highlighting its potential as a therapeutic target. Recent studies have shown that BPTF interacts with various epigenetic regulators and transcription factors, emphasizing its role in complex signaling pathways. Understanding the structure and function of BPTF is crucial for elucidating its mechanisms in health and disease. Research on the restructured form of BPTF aims to decipher its functional implications, investigate its interactions with other proteins, and assess its suitability for drug development. This knowledge could pave the way for novel therapeutic strategies in treating cancers and other disorders linked to aberrant BPTF activity.
