Analytical Data
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Gene name
MAP2K6
- Application
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Alternative Names
MEK6; MKK6; PRKMK6; SAPKK3; SKK3; Stress-activated protein kinase kinase 3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52564
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Expression Region
Phe46~Pro306
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Molecular Weight
36kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP2K6, also known as MKK6, is a member of the mitogen-activated protein kinase (MAPK) kinase family, which plays a crucial role in various cellular processes, including proliferation, differentiation, and stress responses. It specifically activates the p38 MAPK pathway, which is involved in inflammatory responses and apoptosis. Research on MAP2K6 has garnered significant attention due to its implications in several diseases, including cancer and neurodegenerative disorders. The interest in recombinant MAP2K6 protein stems from its potential as a therapeutic target and its utility as a tool for understanding MAPK signaling pathways. By producing and studying MAP2K6 as a recombinant protein, researchers can investigate its biochemical properties, interaction with other signaling molecules, and effects on cellular pathways in both in vitro and in vivo systems. This research not only enhances our understanding of MAPK signaling but also opens avenues for developing novel therapeutic strategies aimed at modulating MAP2K6 activity in disease contexts. The generation of recombinant MAP2K6 protein is crucial for high-throughput screening of small-molecule inhibitors, understanding the structural biology of this kinase, and elucidating its role in the broader context of MAPK signaling networks.
