Analytical Data
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Gene name
EXOSC2
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简介
EXOSC2 is a non-catalytic RNA exosome complex component that plays an important role in 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation processes. In the nucleus, it helps stabilize the maturation of RNA species and eliminates processing by-products, non-coding transcripts and defective mRNAs. EXOSC2 Protein, Human is the recombinant human-derived EXOSC2 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
EXOSC2; Exosome complex component RRP4; Exosome component 2; Ribosomal RNA-processing protein 4
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13868
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Expression Region
M1-G293
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC2, a core component of the exosome complex, plays a critical role in RNA processing and degradation, which is essential for maintaining cellular RNA homeostasis. The exosome is a multi-protein complex that interacts with various RNA substrates, facilitating their turnover and ensuring the quality control of RNA molecules within the cell. Mutations in EXOSC2 have been associated with diseases, such as a form of neurodegeneration known as pontocerebellar hypoplasia, highlighting its importance in human health. Given its pivotal function in RNA metabolism, researchers have increasingly focused on the characterization of EXOSC2 as a recombinant protein to understand its biochemical properties, interaction dynamics, and structural attributes. The production of EXOSC2 as a recombinant protein allows for in-depth studies using various biochemical and biophysical techniques, which can elucidate its function and role within the exosome complex. Furthermore, understanding EXOSC2's interactions with RNA and other protein partners can provide insights into the molecular mechanisms underlying RNA-related diseases and potential therapeutic strategies. Overall, research on recombinant EXOSC2 is crucial for unraveling the complexities of RNA regulation in eukaryotic cells and advancing our knowledge of the exosome's impact on cellular homeostasis and pathogenesis.
