Analytical Data
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基因名
KBTBD11
- Application
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别名
KBTBD11; Kelch repeat and BTB domain-containing protein 11; Chronic myelogenous leukemia-associated protein; Kelch domain-containing protein 7B
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种属
Human
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表达系统
Baculovirus
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标签
N-StrepⅡ;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94819
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表达区间
E2-P623
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD11, a member of the kelch repeat and BTB (BR-C, tTA, Bric a brac) domain containing proteins, has garnered attention due to its potential role in cellular processes such as protein degradation and intracellular signaling. Research indicates that KBTBD11 may function as an E3 ubiquitin ligase, implicating it in the regulation of ubiquitylation pathways, which are critical for maintaining cellular homeostasis and regulating various biological functions. Dysregulation of these pathways has been associated with several diseases, including cancer and neurodegenerative disorders. Thus, the study of KBTBD11 and its recombinant protein forms is crucial for understanding its functional mechanisms and pathological implications. Furthermore, exploring the structural properties and interactions of KBTBD11 can provide insights into its role in the ubiquitin-proteasome system and facilitate the development of targeted therapeutic strategies for diseases linked to its dysfunction. Ongoing investigations aim to elucidate KBTBD11’s structure-function relationships and its contribution to cellular signaling networks, highlighting its importance as a potential biomarker or therapeutic target in disease contexts.
