Analytical Data
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基因名
ING4
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简介
ING4 protein is a component of the HBO1 complex and mediates acetylation of histone H3 at “Lys-14” while reducing the activity of histone H4. ING4 suppresses tumor progression by modulating signaling pathways, inhibiting brain tumor angiogenesis, and specifically inhibiting loss of contact inhibition of oncogenes such as MYC. ING4 Protein, Human (His) is the recombinant human-derived ING4 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Inhibitor of growth protein 4; p29ING4; ING4; My036
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNL4-1
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表达区间
M1-K249
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蛋白长度
Full Length of Isoform-1
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ING4 (Inhibitor of Growth 4) is a member of the ING family of tumor suppressor proteins, which are characterized by their ability to interact with histone acetylation and regulate gene expression. Research has shown that ING4 plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and DNA damage response. It is primarily known for its potential involvement in cancer biology, as downregulation or loss of ING4 expression has been associated with the progression of several types of malignancies. Given its critical functions, ING4 has gained attention as a target for cancer therapy. Studies have indicated that ING4 can enhance p53 activity and promote apoptosis in cancer cells, positioning it as a potential biomarker for cancer prognosis. Furthermore, investigations into its structure and function may reveal new insights into its mechanisms of action, paving the way for the development of novel therapeutic strategies aimed at restoring its function in cancer cells or leveraging its pathways for treatment. As such, ING4 represents a promising candidate for further exploration in the field of cancer research, with implications not only for understanding tumor biology but also for potential therapeutic interventions.
