Analytical Data
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Gene name
COPS5
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简介
The COPS5 protein is a possible protease subunit of the COP9 signalosome complex (CSN) and regulates the ubiquitin conjugation pathway by demethylating the cullin subunit of the SCF-type E3 ligase complex. This activity reduces Ubl ligase activity, affecting complexes such as SCF, CSA, or DDB2. COPS5 Protein, Human (Sf9, Fc) is the recombinant human-derived COPS5 protein, expressed by sf9 insect cells, with C-hFc labeled tag.
- Application
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Alternative Names
COPS5; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein 1
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Species
Human
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Source
Baculovirus
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92905
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Expression Region
A2-S334
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Molecular Weight
33 kDa & 64-66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPS5, also known as COP9 signalosome subunit 5, is a crucial component of the COP9 signalosome, which plays a pivotal role in various cellular processes, including protein degradation, signal transduction, and cell cycle regulation. Research has highlighted the significance of COPS5 in the modulation of the ubiquitin-proteasome system, where it acts as a regulator of protein stability by influencing the activity of E3 ubiquitin ligases. Abnormal expression of COPS5 has been implicated in several diseases, particularly in various types of cancers, where it facilitates tumorigenesis by preventing the degradation of oncoproteins and promoting cell survival. As a result, COPS5 has emerged as a potential therapeutic target. Studies have focused on the structural and functional characterization of COPS5 to uncover its mechanisms of action and interactions with other cellular components. This research includes the development of recombinant COPS5 proteins to study their biochemical properties and to develop inhibitors that could disrupt its function. Such studies are essential for understanding how COPS5 contributes to cellular homeostasis and disease progression, potentially leading to innovative treatments that could leverage the modulation of the COP9 signalosome pathway.
