Analytical Data
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Gene name
Tenascin/Tnc
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简介
Tenascin/Tnc proteins guide neuronal and axonal migration and contribute to development, synaptic plasticity, and neuronal regeneration.Tenascin/Tnc protein, Mouse (HEK293, His) is the recombinant mouse-derived Tenascin/Tnc protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
TN; Hexabrachion; Tenascin-C; TN-C; TNC; Hxb
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Species
Mouse
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q80YX1-1
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Expression Region
G23-S621
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Protein Length
Partial
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Molecular Weight
70-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tenascin-C (Tnc) is an extracellular matrix protein that plays a crucial role in various physiological and pathological processes, including embryogenesis, tissue remodeling, and wound healing. It is known for its modular structure and ability to interact with other matrix components and cell receptors, which influences cell adhesion, proliferation, and migration. Research has shown that Tnc is upregulated in various conditions such as cancer, fibrosis, and inflammatory diseases, making it a potential biomarker for these conditions. The recombinant production of Tenascin-C has gained interest as it allows for the detailed study of its biochemical properties and functional roles. By producing Tnc in a controlled manner, researchers can investigate its effects on cellular behavior and explore its therapeutic potentials or as a target for drug development. Additionally, the ability to manipulate Tnc in a laboratory setting enhances our understanding of its role in the extracellular matrix and its influence on cell signaling pathways. The study of recombinant Tenascin-C thus not only contributes to the fundamental knowledge of extracellular matrix biology but also holds promise for developing innovative treatments for various diseases associated with altered Tnc expression.
