Analytical Data
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Gene name
Fetal-tau/0N3R
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简介
Tau/0N3R protein is encoded by the Tau/0N3R gene and undergoes regulated alternative splicing to produce different mRNA species. Its expression varies in the nervous system according to the maturation and type of neurons. Tau/0N3R Protein, Human (His, solution) is the recombinant human-derived Tau/0N3R protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
MAPT; Mtapt; Tau; Microtubule-associated protein tau; PHF-tau
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10636-2
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Expression Region
A2-L352
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Protein Length
Full Length of Isoform-2 Mature Protein
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Molecular Weight
40-50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fetal-tau/0N3R recombinant protein is an important subject of research, particularly in the context of neurodegenerative diseases such as Alzheimer's. Tau proteins play a crucial role in stabilizing microtubules in neurons, but mutations or hyperphosphorylation of tau can lead to neurofibrillary tangles, a hallmark of Alzheimer’s disease. The 0N3R isoform of tau specifically represents one of the most abundant forms in the adult brain, characterized by its three repeated domains necessary for binding to microtubules. Research into the Fetal-tau/0N3R isoform aims to elucidate the differential roles of tau during development versus its pathological functions in the adult brain. By studying this recombinant protein, scientists hope to better understand the mechanisms of tau pathology, ultimately aiding in the development of targeted therapies for tau-related disorders. This research is also vital in exploring how the transition from fetal to adult tau isoforms influences brain development and plasticity, providing insight into normal cognitive functions and the pathology of neurodegenerative conditions.
