Analytical Data
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基因名
Fetal-tau/0N3R
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简介
Tau/0N3R protein is encoded by the Tau/0N3R gene and undergoes regulated alternative splicing to produce different mRNA species. Its expression varies in the nervous system according to the maturation and type of neurons. Tau/0N3R Protein, Human (His, solution) is the recombinant human-derived Tau/0N3R protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
MAPT; Mtapt; Tau; Microtubule-associated protein tau; PHF-tau
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10636-2
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表达区间
A2-L352
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蛋白长度
Full Length of Isoform-2 Mature Protein
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分子量
40-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fetal-tau/0N3R recombinant protein is an important subject of research, particularly in the context of neurodegenerative diseases such as Alzheimer's. Tau proteins play a crucial role in stabilizing microtubules in neurons, but mutations or hyperphosphorylation of tau can lead to neurofibrillary tangles, a hallmark of Alzheimer’s disease. The 0N3R isoform of tau specifically represents one of the most abundant forms in the adult brain, characterized by its three repeated domains necessary for binding to microtubules. Research into the Fetal-tau/0N3R isoform aims to elucidate the differential roles of tau during development versus its pathological functions in the adult brain. By studying this recombinant protein, scientists hope to better understand the mechanisms of tau pathology, ultimately aiding in the development of targeted therapies for tau-related disorders. This research is also vital in exploring how the transition from fetal to adult tau isoforms influences brain development and plasticity, providing insight into normal cognitive functions and the pathology of neurodegenerative conditions.
